We are seeking a Chemical Biology Research Scientist. Our mission is to develop treatments for serious diseases, including those with traditionally difficult-to-drug targets. In this lab-based role, the scientist will apply novel covalent drug discovery techniques to identify and validate ligands for challenging proteins. The ideal candidate is a motivated, detail-oriented, and lifelong learner with expertise in covalent drug discovery and compound screening.
Key Responsibilities:
Conduct high-throughput compound screening
Design, execute, and troubleshoot novel screening approaches for covalent ligand discovery
Proactively communicate verbally and in writing to engage effectively with multidisciplinary team members
Collaborate with team members to coordinate screening stages and timelines
Knowledge and Skills:
Expertise in covalent chemoproteomics and data analysis
Strong understanding of compound binding affinity, selectivity, reactivity, and kinetics
Experience with automation for liquid handling
Proficiency in affinity capture methods, including immunoprecipitation
Experience with Western blot analysis
Strong background in cell biology, including cell culture and lentiviral-based expression
Requirements
Education and Experience:
Ph.D. in Chemistry, Biochemistry, Chemical Biology, or a related field; or
Master's degree with at least 3 years of relevant experience
Hands-on experience in covalent drug discovery, compound screening, and biochemical assays
Strong track record of scientific research and problem-solving in a laboratory setting
Seniority level
Mid-Senior level
Employment type
Contract
Job function
Science
Industries
IT Services and IT Consulting
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